Send to:

Choose Destination
See comment in PubMed Commons below
Acta Endocrinol (Copenh). 1984 Oct;107(2):204-6.

DDAVP (1-desamino-8-D-arginine vasopressin) clearance rate.


Utilizing a highly sensitive radioimmunoassay (RIA) for 1-desamino-8-D-arginine vasopressin (DDAVP) and a constant infusion kinetic protocol we measured DDAVP clearance rates (CR) in 6 non-pregnant ewes. Despite mean (and SEM) plasma DDAVP levels as high as 5349 (+/- 151) pg/ml, no changes in blood pressure or heart rate were observed. The CR of DDAVP was 3.6 (+/- 0.2) ml/kg X min. This CR is only 23% of the mean arginine vasopressin (AVP) CR measured in similar animals in an earlier study. The relatively decreased CR of DDAVP appears to account largely for the approximately 5-fold prolongation of antidiuresis of this synthetic derivative relative to AVP.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk