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Farmakol Toksikol. 1984 Jul-Aug;47(4):102-5.

[Comparative evaluation of the effectiveness of hepatoprotective agents in a liver lesion by combined ethanol and tuberculostatic agents].

[Article in Russian]


Chronic experiments on male rats were carried out to study the hepatoprotective action of leganol, essentiale, tocopherol, pyridoxine, ATP and of a phospholipid complex containing phosphatidylserine, phosphatidylethanolamine and sphingomyelin under liver injury caused by combined ethanol, isoniazide and rifampicin. ATP, pyridoxine and tocopherol were not discovered to have the hepatoprotective action. Legalon, essentiale and the phospholipid complex exerted a marked hepatoprotective action, in the mechanism of which of importance are probably the reduced activity of membrane phospholipases and (for phospholipid drugs) substituting action.

[PubMed - indexed for MEDLINE]
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