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Two non-allelic human interferon alpha genes with identical coding regions.
A hitherto undescribed human interferon-alpha (IFN-alpha) gene, IFN-alpha 13, has been isolated and characterized. Its entire coding sequence is completely identical with that of IFN-alpha 1; the 5' and 3' non-coding regions differ by 4.5% and 3.8%, respectively. As the two genes are not allelic, we conclude that the similarity is due to a very recent gene conversion event. Both genes are expressed in virus-induced leukocytes.
PMID: 6479148 [PubMed - indexed for MEDLINE]
PMCID: PMC557600
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Cited by 9 PubMed Central articles
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Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals.
Laukaitis CM, Heger A, Blakley TD, Munclinger P, Ponting CP, Karn RC.
BMC Evol Biol. 2008 Feb 12; 8:46. Epub 2008 Feb 12.
[BMC Evol Biol. 2008]
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Evolution of the interferon alpha gene family in eutherian mammals.
Woelk CH, Frost SD, Richman DD, Higley PE, Kosakovsky Pond SL.
Gene. 2007 Aug 1; 397(1-2):38-50. Epub 2007 Apr 3.
[Gene. 2007]
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Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N.
Biochem J. 1998 Jan 15; 329 ( Pt 2):295-302.
[Biochem J. 1998]
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