Isolation and characterization of the precursor of type M collagen

Biochem J. 1984 Aug 1;221(3):885-9. doi: 10.1042/bj2210885.

Abstract

A 225000-Mr peptide has been purified from rat chondrosarcoma which is immunologically and biochemically related to type M collagen. Rotary shadowing shows this molecule to be twice the length of the type M molecule and has a prominent kink close to one end. We believe this molecule represents parent type M, the form of the molecule in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / immunology
  • Chondrosarcoma / analysis
  • Chromatography, Ion Exchange
  • Electrophoresis, Polyacrylamide Gel
  • Microscopy, Electron
  • Procollagen* / immunology
  • Procollagen* / isolation & purification
  • Protein Conformation
  • Rats
  • Rats, Inbred Strains

Substances

  • Antibodies
  • Procollagen