Bone-marrow transplant from an unrelated donor for chronic granulomatous disease

Lancet. 1977 Jan 29;1(8005):210-3.

Abstract

A boy with chronic granulomatous disease received a bone-marrow graft from a fully compatible unrelated donor, in association with a modified immunosuppressant regimen. He showed considerable clinical improvement with definite evidence of engraftment, and he has enjoyed a normal life for over 3 years.

Publication types

  • Case Reports

MeSH terms

  • ABO Blood-Group System
  • Bone Marrow Cells*
  • Bone Marrow Transplantation*
  • Child
  • Cyclophosphamide / therapeutic use
  • Female
  • Graft Survival
  • Granulomatous Disease, Chronic / genetics
  • Granulomatous Disease, Chronic / immunology
  • Granulomatous Disease, Chronic / therapy*
  • HLA Antigens / analysis
  • Histocompatibility Testing
  • Humans
  • Lymphocyte Culture Test, Mixed
  • Male
  • Neutrophils
  • Nitroblue Tetrazolium
  • Phagocyte Bactericidal Dysfunction / therapy*
  • Preoperative Care
  • Rh-Hr Blood-Group System
  • Sex Chromosome Aberrations
  • Tissue Donors
  • Transplantation, Homologous

Substances

  • ABO Blood-Group System
  • HLA Antigens
  • Rh-Hr Blood-Group System
  • Nitroblue Tetrazolium
  • Cyclophosphamide