The testing of 4CMB, 4HMB and BC for mutagenicity in a new Neurospora crassa heterokaryon

Mutat Res. 1982 Jan-Feb;100(1-4):123-6. doi: 10.1016/0165-1218(82)90032-5.

Abstract

This genetic system permits both point mutations and deletion to be detected in the same experimental material. 4CMB and BC are regarded as being mutagenic in this system. 4HMB induced mutations in only 1 of the 3 treatment protocols used, and its mutagenicity is questionable.

Publication types

  • Comparative Study

MeSH terms

  • Benzyl Compounds / pharmacology*
  • Biphenyl Compounds / pharmacology*
  • Mutagenicity Tests
  • Mutagens / pharmacology*
  • Mutation*
  • Neurospora / drug effects*
  • Neurospora crassa / drug effects*
  • Species Specificity
  • Structure-Activity Relationship

Substances

  • Benzyl Compounds
  • Biphenyl Compounds
  • Mutagens
  • 4-hydroxymethylbiphenyl
  • 4-chloromethylbiphenyl
  • benzyl chloride