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Instituto de Biología Molecular CSIC, Centro de Biología Molecular, Madrid, Spain.
Peptidoglycan peptide-interacting proteins (PPIPs) which include the penicillin-binding proteins (PBPs) are bacterial enzymes which interact with beta-lactams (including penicillins and cephalosporins) and/or acyl-D-ala-D-ala analogues of a non-beta-lactam structure. The PBPs and other PPIPs of Escherichia coli are reviewed.
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