Ther Drug Monit. 1984;6(3):272-6.

Valproic acid in breast milk: how much is really there?

von Unruh GE, Froescher W, Hoffmann F, Niesen M.

Abstract

Valproic acid (VPA) concentrations were measured by a sensitive and highly specific gas chromatographic/mass spectrometric assay in breast milk from 16 patients treated with VPA during 17 lactation periods. The range of VPA levels in 36 breast milk samples was 0.4-3.9 micrograms/ml (mean 1.9 +/- 1.2 microgram/ml). During the investigations of breast milk it was found that the concentration of total VPA in breast milk was not much higher than that of unbound VPA. These findings agree with clinical observations of infants fed with milk from VPA-treated mothers.

PMID:: 6438834; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Valproic Acid

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Molecular Biology Databases

VALPROIC ACID - HSDB

Supplemental Content

Save items

Related citations in PubMed

Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites. [J Pediatr. 1984]
Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites.
Nau H, Helge H, Luck W. J Pediatr. 1984 Apr; 104(4):627-34.
Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques. [Biomed Environ Mass Spectrom. ...]
Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques.
Rettenmeier AW, Howald WN, Levy RH, Witek DJ, Gordon WP, Porubek DJ, Baillie TA. Biomed Environ Mass Spectrom. 1989 Mar; 18(3):192-9.
Negative ion chemical ionization gas chromatography/mass spectrometry of valproic acid metabolites. [Biomed Environ Mass Spectrom. ...]
Negative ion chemical ionization gas chromatography/mass spectrometry of valproic acid metabolites.
Kassahun K, Burton R, Abbott FS. Biomed Environ Mass Spectrom. 1989 Oct; 18(10):918-26.
Review Three cases of delivery under sodium valproate--placental transfer, milk transfer and probable teratogenicity of sodium valproate. [Jpn J Psychiatry Neurol. 1988]
Review Three cases of delivery under sodium valproate--placental transfer, milk transfer and probable teratogenicity of sodium valproate.
Tsuru N, Maeda T, Tsuruoka M. Jpn J Psychiatry Neurol. 1988 Mar; 42(1):89-96.
Review Constituents of saliva and breast milk. [Suppl Int J Gynecol Obstet. 1989]
Review Constituents of saliva and breast milk.
Albertson BD. Suppl Int J Gynecol Obstet. 1989; 1:53-65.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Valproic acid in breast milk: how much is really there?
Valproic acid in breast milk: how much is really there?
Ther Drug Monit. 1984 ;6(3):272-6.

PubMed
The relative merits and drawbacks of new nucleoside analogues with clinical pote...
The relative merits and drawbacks of new nucleoside analogues with clinical potential.
J Antimicrob Chemother. 1984 Aug ;14 Suppl A:5-26.

PubMed
Serratia marcescens contamination of antiseptic soap containing triclosan: impli...
Serratia marcescens contamination of antiseptic soap containing triclosan: implications for nosocomial infection.
Infect Control. 1984 Sep ;5(9):427-30.

PubMed
Diazepam tapering in detoxification for high-dose benzodiazepine abuse.
Diazepam tapering in detoxification for high-dose benzodiazepine abuse.
Clin Pharmacol Ther. 1984 Oct ;36(4):527-33.

PubMed
Blood lead concentration, blood pressure, and renal function.
Blood lead concentration, blood pressure, and renal function.
Br Med J (Clin Res Ed). 1984 Oct 6 ;289(6449):872-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: