Toxicity of antineoplastic drug combinations in vitrectomy infusion fluid

Ophthalmic Surg. 1984 Oct;15(10):844-6.

Abstract

We evaluated a combination of various antineoplastic drugs used in vitrectomy infusion fluid for toxicity. A combination of 250 micrograms/ml of 5-fluorouracil with each of the following agents, 8.0 micrograms/ml of thiotepa or 40 micrograms/ml of etoposide, or 0.1 micrograms/ml doxorubicin, or 0.1 microgram/ml vincristine was tolerated well in the rabbit eyes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / toxicity*
  • Doxorubicin / toxicity
  • Etoposide / toxicity
  • Fluorouracil / toxicity
  • Ophthalmic Solutions / toxicity*
  • Rabbits
  • Thiotepa / toxicity
  • Vincristine / toxicity
  • Vitrectomy*

Substances

  • Ophthalmic Solutions
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Thiotepa
  • Fluorouracil