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    Nature. 1984 Nov 22-28;312(5992):342-7.

    Molecular cloning of a cDNA encoding human antihaemophilic factor.

    Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker JL, Pittman DD, Kaufman RJ, Brown E, Shoemaker C, Orr EC, et al.

    A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.

    PMID: 6438528 [PubMed - indexed for MEDLINE]

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