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Nature. 1984 Nov 22-28;312(5992):337-42.

Structure of human factor VIII.

Abstract

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.

PMID:
6438527
[PubMed - indexed for MEDLINE]
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