Proc Natl Acad Sci U S A. 1983 Oct;80(20):6303-6.

Membership mutation of the genetic code: loss of fitness by tryptophan.

Abstract

Bacillus subtilis strain QB928, a tryptophan-auxotroph, was serially mutated to yield strain HR15. For QB928, tryptophan functioned as a competent amino acid and 4-fluorotryptophan as merely an inferior analogue. For HR15, these roles were reversed. The tryptophan/4-fluorotryptophan growth ratio decreased by a factor of 2 X 10(4) in the transition from QB928 to HR15.

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Membership mutation of the genetic code: loss of fitness by tryptophan.
Membership mutation of the genetic code: loss of fitness by tryptophan.
Proc Natl Acad Sci U S A. 1983 Oct ;80(20):6303-6.

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Membership mutation of the genetic code: loss of fitness by tryptophan.

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