Three hundred fifty-four patients with taste and/or smell disorders were evaluated with computed tomography (CT). The largest group was characterized by head trauma (27%), followed by idiopathic causes (26%), postinfluenza-like hyposmia and hypogeusia (15%), and congenital etiologies (14%). Hyposmia and hypogeusia occurred concomitantly in 21%-45%, the percentage varying according to etiologic subgroup. CT abnormalities were found in 108 (31%) of the 354 patients. The most frequent pathologies were frontal encephalomalacia, subfrontal atrophy in the region of the olfactory bulbs, and anterior temporal lobe atrophy. These changes were found alone or in tandem. Some CT findings suggest common cerebral taste and smell centers and common neural pathways and association centers.