-
Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion.
The incidence of convulsions in patients receiving tricyclic antidepressants or bupropion was reviewed. For both types of drug, the risk of a seizure was dose-dependent and was higher in patients with predisposing factors, e.g., a history of seizures. Patients without a predisposing factor had a convulsion incidence of approximately 0.6%-0.9% (6-9/1,000 patients) when receiving imipramine at doses of greater than 200 mg/day or bupropion at doses greater than 450 mg/day. At lower doses, the frequency of seizures dropped to about 1/1,000 (or less) for imipramine and bupropion. Thus, the risk of a seizure in patients receiving equally therapeutic doses of imipramine and bupropion appears to be comparable.
PMID: 6406457 [PubMed - indexed for MEDLINE]
-
Cited by 6 PubMed Central articles
-
Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents.
Henshall DC, Dürmüller N, White HS, Williams R, Moser P, Dunleavy M, Silverstone PH.
Neuropsychiatr Dis Treat. 2009; 5:189-206. Epub 2009 Apr 8.
[Neuropsychiatr Dis Treat. 2009]
-
Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice.
Silverstone PH, Williams R, McMahon L, Fleming R, Fogarty S.
Ann Gen Psychiatry. 2008 Dec 23; 7:27. Epub 2008 Dec 23.
[Ann Gen Psychiatry. 2008]
-
Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice.
Silverstone PH, Williams R, McMahon L, Fleming R, Fogarty S.
Ann Gen Psychiatry. 2008 Oct 15; 7:19. Epub 2008 Oct 15.
[Ann Gen Psychiatry. 2008]
- » See all...