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Structure and expression of a cloned cDNA for human interleukin-2.
A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The DNA sequence codes for a polypeptide which consists of 153 amino acids including a putative signal sequence. A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells.
PMID: 6403867 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Biological significance of soluble IL-2 receptor.
Caruso C, Candore G, Cigna D, Colucci AT, Modica MA.
Mediators Inflamm. 1993; 2(1):3-21.
[Mediators Inflamm. 1993]
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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.
Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA.
Immunity. 2008 May; 28(5):687-97. Epub 2008 May 8.
[Immunity. 2008]
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ReviewBloodlines of haematopoietic stem cell research in Japan.
Ema H, Nakauchi H.
Philos Trans R Soc Lond B Biol Sci. 2008 Jun 27; 363(1500):2089-97.
[Philos Trans R Soc Lond B Biol Sci. 2008]
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