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J Biomol Struct Dyn. 1983 Oct;1(2):509-21.

Possible molecular detent in the DNA structure at regulatory sequences.

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  • 1Department of Chemistry, University of Pennsylvania, Philadelphia 19104.


A common feature that appears in a number of DNA sites where proteins interact is the sequence GTG/CAC. In the lac operator this sequence leads to a region with a higher imino proton exchange rate well below the optical melting temperature. It is suggested that this reflects a structural feature recognized by proteins that bind specific sites on the DNA molecule.

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