Childs Brain. 1978;4(2):74-82.

Cerebrospinal fluid antibiotic concentrations in ventricular shunt infections.

Wilson HD, Bean JR, James HE, Pendley MM.

Abstract

The concentration of antibiotic in cerebrospinal fluid was measured during treatment of seven children with infected ventricular shunts. Antibiotics were administered via the ventricular shunt or through an external ventricular drain. 53 CSF samples were obtained 7-19 h after antibiotic administration. Wide variation in cerebrospinal fluid antibiotic concentration occurred from patient to patient following either route of administration. For optimal management of shunt infections, we recommend periodic assessment of antibiotic concentration or activity in ventricular fluid and determination of the minimum inhibitory concentration of antibiotic required for each pathogen.

PMID:: 639602; [PubMed - indexed for MEDLINE]

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Cerebrospinal fluid antibiotic levels during treatment of shunt infections. [J Neurosurg. 1980]
Cerebrospinal fluid antibiotic levels during treatment of shunt infections.
Wald SL, McLaurin RL. J Neurosurg. 1980 Jan; 52(1):41-6.
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Cited by 1 PubMed Central article

Staphylococcus aureus ventriculitis treated with single-dose intraventricular vancomycin or daptomycin (LY146032): bacterial and antibiotic kinetics in hydrocephalic rabbits. [Antimicrob Agents Chemother. 1...]
Staphylococcus aureus ventriculitis treated with single-dose intraventricular vancomycin or daptomycin (LY146032): bacterial and antibiotic kinetics in hydrocephalic rabbits.
Haworth CS, Sobieski MW, Scheld WM, Park TS. Antimicrob Agents Chemother. 1990 Feb; 34(2):245-51.

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