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Biochem J. 1984 Dec 1;224(2):685-8.

Effect of insulin on glucose metabolism in adipocytes from virgin and late-pregnant rats.

Abstract

Under basal conditions (zero insulin), paraovarian adipocytes from 19-day-pregnant rats exhibited the same rates of [U-14C]glucose conversion into CO2 and total lipids as did those from age-matched virgin rats. The dose-response curves for insulin stimulation of glucose metabolism were similar in both groups: maximal response (+100% over basal values) and high sensitivity (half-maximal effect at 0.05 nM-insulin). The present results suggest that the insulin resistance in vivo that occurs during late pregnancy may involve circulating factors lost in vitro.

PMID:
6393953
[PubMed - indexed for MEDLINE]
PMCID:
PMC1144483
Free PMC Article
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