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    Nature. 1984 Dec 20-1985 Jan 2;312(5996):724-9.

    Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

    Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV.

    Abstract

    Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.

    PMID:
    6392892
    [PubMed - indexed for MEDLINE]

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