Blood. 1984 Mar;63(3):629-33.

Diminished activity of a chemotactic inhibitor in synovial fluids from patients with familial Mediterranean fever.

Matzner Y, Partridge RE, Levy M, Babior BM.

Abstract

Synovial fluids from patients with osteoarthritis contain a chemotactic inhibitor that acts by antagonizing the complement-derived chemotactic anaphylotoxin, C5a. The activity of this inhibitor in synovial fluids from patients with several forms of inflammatory arthritis (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and gout) were comparable to the activity present in osteoarthritic synovial fluids. In contrast, levels of inhibitory activity in synovial fluids from 9 patients with familial Mediterranean fever were decreased to less than 20% of those found in osteoarthritis fluids. The possibility was considered that the diminished inhibitory activity in fluids from patients with familial Mediterranean fever plays a part in the pathogenesis of the inflammatory attacks characteristic of this disease.

PMID:: 6365203; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Medical

familial Mediterranean fever - Genetics Home Reference

Supplemental Content

Save items

Related citations in PubMed

C5a-inhibitor deficiency in peritoneal fluids from patients with familial Mediterranean fever. [N Engl J Med. 1984]
C5a-inhibitor deficiency in peritoneal fluids from patients with familial Mediterranean fever.
Matzner Y, Brzezinski A. N Engl J Med. 1984 Aug 2; 311(5):287-90.
Proposed mechanism of the inflammatory attacks in familial Mediterranean fever. [Arch Intern Med. 1990]
Proposed mechanism of the inflammatory attacks in familial Mediterranean fever.
Matzner Y, Ayesh SK, Hochner-Celniker D, Ackerman Z, Ferne M. Arch Intern Med. 1990 Jun; 150(6):1289-91.
Complement C4-derived monocyte-directed chemotaxis-inhibitory factor. A molecular mechanism to cause polymorphonuclear leukocyte-predominant infiltration in rheumatoid arthritis synovial cavities. [Am J Pathol. 1991]
Complement C4-derived monocyte-directed chemotaxis-inhibitory factor. A molecular mechanism to cause polymorphonuclear leukocyte-predominant infiltration in rheumatoid arthritis synovial cavities.
Matsubara S, Yamamoto T, Tsuruta T, Takagi K, Kambara T. Am J Pathol. 1991 May; 138(5):1279-91.
Comparison of synovial MMP-1 and TIMP-1 levels in patients with various inflammatory arthritides: is there any difference between rheumatoid arthritis, Behçet's disease and familial Mediterranean fever? [Clin Rheumatol. 2002]
Comparison of synovial MMP-1 and TIMP-1 levels in patients with various inflammatory arthritides: is there any difference between rheumatoid arthritis, Behçet's disease and familial Mediterranean fever?
Pay S, Erdem H, Serdar M, Dinç A, Simşek I, Turan M. Clin Rheumatol. 2002 Nov; 21(6):511-5.
Review [Familial Mediterranean Fever (FMF): from diagnosis to treatment]. [Sante. 2004]
Review [Familial Mediterranean Fever (FMF): from diagnosis to treatment].
Medlej-Hashim M, Loiselet J, Lefranc G, Mégarbané A. Sante. 2004 Oct-Dec; 14(4):261-6.

See reviews... See all...

Cited by 2 PubMed Central articles

Serum soluble interleukin-2 receptor levels in familial Mediterranean fever. [Ann Rheum Dis. 1996]
Serum soluble interleukin-2 receptor levels in familial Mediterranean fever.
Erken E, Güneşaçar R, Ozbek S, Konca K. Ann Rheum Dis. 1996 Nov; 55(11):852-5.
Circulating hydroxy fatty acids in familial Mediterranean fever. [Proc Natl Acad Sci U S A. 1985]
Circulating hydroxy fatty acids in familial Mediterranean fever.
Aisen PS, Haines KA, Given W, Abramson SB, Pras M, Serhan C, Hamberg M, Samuelsson B, Weissmann G. Proc Natl Acad Sci U S A. 1985 Feb; 82(4):1232-6.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Diminished activity of a chemotactic inhibitor in synovial fluids from patients ...
Diminished activity of a chemotactic inhibitor in synovial fluids from patients with familial Mediterranean fever.
Blood. 1984 Mar ;63(3):629-33.

PubMed
The stem cell system.
The stem cell system.
Biomed Pharmacother. 1983 ;37(8):375-80.

PubMed
Reye's syndrome. A review from the forensic viewpoint.
Reye's syndrome. A review from the forensic viewpoint.
Am J Forensic Med Pathol. 1983 Dec ;4(4):323-9.

PubMed
Benign X-linked muscular dystrophy (Becker type): a kindred with very slow rate ...
Benign X-linked muscular dystrophy (Becker type): a kindred with very slow rate of progression.
Acta Neurol Scand. 1983 Nov ;68(5):344-9.

PubMed
[Stauffer's syndrome. Reversible hepatic dysfunction in renal cell carcinoma (au...
[Stauffer's syndrome. Reversible hepatic dysfunction in renal cell carcinoma (author's transl)].
Wien Klin Wochenschr. 1978 Apr 14 ;90(8):268-70.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Diminished activity of a chemotactic inhibitor in synovial fluids from patients with familial Mediterranean fever.

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information