Nature. 1983 Sep 15-21;305(5931):189-93.

Construction of artificial chromosomes in yeast.

Abstract

Fifty-five-kilobase long artificial chromosomes containing cloned genes, replicators, centromeres and telomeres have been constructed in yeast. These molecules have many of the properties of natural yeast chromosomes. Centromere function is impaired on short (less than 20 kilobases) artificial chromosomes.

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T32-CA09361/CA/NCI NIH HHS/United States

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Nature. 1983 Sep 15-21 ;305(5931):189-93.

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