Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin

Nucleic Acids Res. 1983 Jul 25;11(14):4703-12. doi: 10.1093/nar/11.14.4703.

Abstract

The complete nucleotide sequence of the hemagglutinin (HA) gene of the human type B influenza virus B/Singapore/222/79 is presented. Comparison with the only other known sequence of a B hemagglutinin (B/Lee/40) shows that antigenic drift in type B HA genes is essentially the same as already observed within the influenza A H3 subtype, i.e., an accumulation of point mutations. The main difference is that the apparent evolution is significantly slower, most likely due to the cumulative effect of a lower occurrence in the population (slower evolution) and/or less immunological pressure. There is a striking cluster of changes at positions 127 until 137 of the HA1 subunit which may represent one of the antigenic sites of the molecule.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Ampicillin / pharmacology
  • Base Sequence*
  • Escherichia coli / genetics
  • Genes*
  • Genes, Viral*
  • Glycosides / analysis
  • Hemagglutinins / genetics*
  • Orthomyxoviridae / genetics*
  • Penicillin Resistance
  • Plasmids
  • Species Specificity
  • Tetracycline / pharmacology

Substances

  • Glycosides
  • Hemagglutinins
  • Ampicillin
  • Tetracycline

Associated data

  • GENBANK/K00038