Abstract
Nine patients are described with hereditary clotting factor abnormalities and thrombosis and 35 others previously reported in the literature. An additional 11 patients with myocardial infarction observed by the authors and 12 more reported by others are also included. A patient with non-immune thrombocytopenia and myocardial infarction is presented, as well as three additional patients recorded in the literature. This study underscores the little-recognized phenomenon of uncontrolled thrombosis in these patients with "experiments of nature," in whom clotting studies reflect an impairment of coagulation comparable in degree to that achieved by oral anticoagulant therapy.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adult
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Blood Coagulation Disorders / blood
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Blood Coagulation Disorders / congenital*
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Blood Coagulation Disorders / epidemiology
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Blood Coagulation Factors / analysis*
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Factor V Deficiency / blood
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Factor X Deficiency / blood
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Factor XI Deficiency / blood
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Factor XII Deficiency / blood
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Female
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Fibrinogen / analysis
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Hemophilia A / blood
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Hemophilia B / blood
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Humans
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Kininogens / analysis
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Male
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Middle Aged
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Myocardial Infarction / etiology*
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Ohio
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Prekallikrein / analysis
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Thrombocytopenia / congenital*
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Thrombosis / etiology*
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von Willebrand Diseases / blood
Substances
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Blood Coagulation Factors
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Kininogens
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Fibrinogen
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Prekallikrein