Comparative side effects of imipramine, benztropine, or their combination in patients receiving fluphenazine decanoate

Am J Psychiatry. 1983 Aug;140(8):1069-71. doi: 10.1176/ajp.140.8.1069.

Abstract

Patients receiving fluphenazine decanoate who were switched from adjunctive benztropine to imipramine in a double-blind trial experienced marked exacerbations of extrapyramidal side effects. No substantial increase in anticholinergic side effects occurred, however, when imipramine was added to fluphenazine decanoate and benztropine.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Benztropine / adverse effects*
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Dyskinesia, Drug-Induced / etiology*
  • Dyskinesia, Drug-Induced / prevention & control
  • Female
  • Fluphenazine / analogs & derivatives
  • Humans
  • Imipramine / adverse effects*
  • Male
  • Middle Aged
  • Tropanes / adverse effects*

Substances

  • Tropanes
  • Benztropine
  • fluphenazine depot
  • Imipramine
  • Fluphenazine