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The rfaD gene codes for ADP-L-glycero-D-mannoheptose-6-epimerase. An enzyme required for lipopolysaccharide core biosynthesis.
The rfaD gene product, ADP-L-glycero-D-mannoheptose-6-epimerase, is necessary for the conversion of ADP-D-glycero-D-mannoheptose to ADP-L-glycero-D-mannoheptose. The nucleotide ADP-D-glycero-D-mannoheptose accumulates in rfaD mutant strains. Two chimeric colicin E1 plasmids carrying the coding sequence of the rfaD+ locus have been selected and shown to complement the rfaD phenotype. These clones also result in an amplification of ADP-L-glycero-D-mannoheptose-6-epimerase activity.
PMID: 6337148 [PubMed - indexed for MEDLINE]
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Cited by 18 PubMed Central articles
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[J Bacteriol. 2004]
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ReviewLipopolysaccharide endotoxins.
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[Annu Rev Biochem. 2002]
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Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
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[J Bacteriol. 2002]
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