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    Pharmacol Biochem Behav. 1984 May;20(5):675-9.

    Stress and sucrose hyperphagia: role of endogenous opiates.

    Bertiere MC, Sy TM, Baigts F, Mandenoff A, Apfelbaum M.

    Two experimental situations induce hyperphagia in the rat: the cafeteria model and the tail-pinching model. In non-deprived rats which are offered for one hour a choice of 3 liquid cafeteria items in addition to ordinary chow and water, mild tail-pinching results in a preferential sucrose hyperphagia; naltrexone (2.5 mg/kg IP) suppresses this stress-induced hyperphagia; beta-endorphin (3 micrograms ICV) has the same effect. This apparent discrepancy is discussed: the antagonist may suppress the hyperphagia because it suppresses the reward provoked by the sucrose, the agonist because it makes it unnecessary.

    PMID: 6330761 [PubMed - indexed for MEDLINE]

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      Naltrexone is used along with counseling and social support to help people who have stopped drinking alcohol and using street drugs continue to avoid drinking or using drugs. Naltrexone should not be used to treat people...