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J Nucl Med. 1978 Mar;19(3):284-6.

Human reaction to bovine TSH: concise communication.


The incidence of allergic reactions to bovine TSH and its relation to dose have been studied in 42 patients with thyroid cancer who had total ablation of functioning thyroidal tissue and have been followed prospectively for up to 25 yr. Of these patients, 43% showed an allergic reaction to bovine TSH. The remaining 57% have shown no reaction, even though they have received cumulative TSH doses larger than those who did show a reaction. The reaction rate is linear up to a cumulative dose of 150 units and is not dose-related therafter.

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