Toxicity of 2-deoxygalactose to Saccharomyces cere...[Mol Cell Biol. 1984]

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1: Mol Cell Biol. 1984 May;4(5):994-6. Links

Toxicity of 2-deoxygalactose to Saccharomyces cerevisiae cells constitutively synthesizing galactose-metabolizing enzymes.

Platt T.

Analysis of 400 independent spontaneous mutations conferring 2-deoxygalactose resistance upon cells constitutive for the galactose pathway suggests that toxicity is due to 2-deoxygalactose-1-phosphate. Selection for and against growth on galactose in the same strain is now possible; application to systems with transcriptional or translational gene fusions to galactokinase are discussed.

PMID: 6328283 [PubMed - indexed for MEDLINE]

PMCID: PMC368858

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