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Proc Natl Acad Sci U S A. 1984 Apr;81(7):2097-101.

Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.

Abstract

Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.

PMID:
6326104
PMCID:
PMC345444
[PubMed - indexed for MEDLINE]
Free PMC Article
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