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Chromosomal localisation of the human homologues to the oncogenes erbA and B.
Avian erythroblastosis virus (AEV) induces acute erythroleukemia and sarcomas in vivo and it transforms erythroblasts and fibroblasts in vitro. The virus has two host cell-derived genes, v-erbA and v-erbB. The latter encodes the oncogenic capacity of the virus, whereas v-erbA enhances the erythroblast transforming effects of v-erbB while being unable to induce neoplasms independently. Recently, human cellular homologues of these viral erb genes have been isolated. The chromosomal locations of two of these genes have been determined using EcoRI-digested DNA prepared from human-mouse somatic cell hybrids. The human c-erbA1 gene has been assigned to chromosome 17 and is located between 17p11 and 17q21. The human c-erbB sequence has been assigned to chromosome 7 and is located between 7pter and 7q22. Thus, in the human genome these genes are on two separate chromosomes. No evidence for the involvement of the human c-erb genes in neoplasia has been found.
PMID: 6323162 [PubMed - indexed for MEDLINE]
PMCID: PMC557313
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Cited by 20 PubMed Central articles
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A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.
Dayton AI, Selden JR, Laws G, Dorney DJ, Finan J, Tripputi P, Emanuel BS, Rovera G, Nowell PC, Croce CM.
Proc Natl Acad Sci U S A. 1984 Jul; 81(14):4495-9.
[Proc Natl Acad Sci U S A. 1984]
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Cellular oncogenes (c-erb-A and c-erb-B) located on different chicken chromosomes can be transduced into the same retroviral genome.
Symonds G, Stubblefield E, Guyaux M, Bishop JM.
Mol Cell Biol. 1984 Aug; 4(8):1627-30.
[Mol Cell Biol. 1984]
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Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man.
Zabel BU, Fournier RE, Lalley PA, Naylor SL, Sakaguchi AY.
Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4874-8.
[Proc Natl Acad Sci U S A. 1984]
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