TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes reduction in the low density lipoprotein (LDL) receptor activities in the hepatic plasma membrane of the guinea pig and rat

Biochem Biophys Res Commun. 1984 Jan 30;118(2):548-54. doi: 10.1016/0006-291x(84)91337-8.

Abstract

Administration of 1 micrograms/kg (single intraperitoneal injection and studied after 10 days) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to young male guinea pigs was found to cause a significant reduction in binding of low-density lipoprotein (LDL) to its receptor on the hepatic plasma membrane. This reduction in LDL binding is not caused by the decrease of food intake by treated animals since pair-fed control animals had significantly higher LDL binding than treated animals. It was also found that primary hepatocytes from treated animals had a reduced ability to internalize LDL than controls. Such a change in the plasma membrane function may explain the resulting hyperlipidemia particularly hypercholesterolemia which occurs in this species as a result of TCDD administration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • DDT / pharmacology
  • Dioxins / pharmacology*
  • Guinea Pigs
  • Kinetics
  • Lipoproteins, LDL / metabolism*
  • Liver / drug effects
  • Liver / metabolism*
  • Polychlorinated Dibenzodioxins / pharmacology*
  • Rats
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / metabolism*
  • Receptors, LDL
  • Species Specificity

Substances

  • Dioxins
  • Lipoproteins, LDL
  • Polychlorinated Dibenzodioxins
  • Receptors, Cell Surface
  • Receptors, LDL
  • DDT