Med Hypotheses. 1983 Nov;12(3):253-68.

The Na,K-ATPase hypothesis for manic-depression. I. General considerations.

Abstract

An hypothesis is presented to explain and integrate experimental and clinical observations on manic-depressive (bipolar or biphasic) psychosis. The model is based on alterations in the activity of the sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) pump. A reduction in the activity of the Na,K-ATPase can be responsible for both phases of the disorder.

PMID:: 6321918; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Elsevier Science

Medical

Bipolar Disorder - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

The Na,K-ATPase hypothesis for manic-depression. II. The mechanism of action of lithium. [Med Hypotheses. 1983]
The Na,K-ATPase hypothesis for manic-depression. II. The mechanism of action of lithium.
el-Mallakh RS. Med Hypotheses. 1983 Nov; 12(3):269-82.
Review The Na,K-ATPase hypothesis for bipolar illness. [Biol Psychiatry. 1995]
Review The Na,K-ATPase hypothesis for bipolar illness.
el-Mallakh RS, Wyatt RJ. Biol Psychiatry. 1995 Feb 15; 37(4):235-44.
Sodium-potassium, magnesium, and calcium ATPase activities in erythrocyte membranes from manic-depressive patients responding to lithium. [Biol Psychiatry. 1986]
Sodium-potassium, magnesium, and calcium ATPase activities in erythrocyte membranes from manic-depressive patients responding to lithium.
Alexander DR, Deeb M, Bitar F, Antun F. Biol Psychiatry. 1986 Sep; 21(11):997-1007.
Prediction of clinical course of bipolar manic depressive illness treated with lithium. [Psychol Med. 1980]
Prediction of clinical course of bipolar manic depressive illness treated with lithium.
Johnston BB, Naylor GJ, Dick EG, Hopwood SE, Dick DA. Psychol Med. 1980 May; 10(2):329-34.
Review Is the Na(+)-K(+)-ATPase the link between phosphoinositide metabolism and bipolar disorder? [J Neuropsychiatry Clin Neurosc...]
Review Is the Na(+)-K(+)-ATPase the link between phosphoinositide metabolism and bipolar disorder?
el-Mallakh RS, Li R. J Neuropsychiatry Clin Neurosci. 1993 Fall; 5(4):361-8.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

The Na,K-ATPase hypothesis for manic-depression. I. General considerations.
The Na,K-ATPase hypothesis for manic-depression. I. General considerations.
Med Hypotheses. 1983 Nov ;12(3):253-68.

PubMed
Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal...
Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens.
J Virol. 1984 Apr ;50(1):237-47.

PubMed
Canine parvovirus immunoprophylaxis: a review.
Canine parvovirus immunoprophylaxis: a review.
J S Afr Vet Assoc. 1983 Dec ;54(4):259-64.

PubMed
[A light and electron microscopic studies of müllerian adenofibroma of the uteru...
[A light and electron microscopic studies of müllerian adenofibroma of the uterus].
Nihon Sanka Fujinka Gakkai Zasshi. 1984 Jan ;36(1):44-8.

PubMed
[Chromosome instability syndromes].
[Chromosome instability syndromes].
Sem Hop. 1983 Dec 1 ;59(44):3065-79.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The Na,K-ATPase hypothesis for manic-depression. I. General considerations.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information