Abstract
No significant differences were detected in circulating levels of IgE or IgG1 in hereditarily asplenic (Dh/+) or splenectomized mice compared to normal controls (+/+). These findings suggest that the spleen plays a minor role in the regulation of IgG1 and IgE production in this mouse line.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibody Specificity*
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Immunity, Cellular
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Immunoglobulin E / biosynthesis
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Immunoglobulin G / biosynthesis
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Isoantibodies / analysis*
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Mice
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Ovalbumin / immunology
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Passive Cutaneous Anaphylaxis
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Spleen / abnormalities*
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Splenectomy*
Substances
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Immunoglobulin G
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Isoantibodies
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Immunoglobulin E
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Ovalbumin