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Isolation and structural organization of the human preproenkephalin B gene.
Horikawa S,
Takai T,
Toyosato M,
Takahashi H,
Noda M,
Kakidani H,
Kubo T,
Hirose T,
Inayama S,
Hayashida H, et al.
The primary structure of porcine preproenkephalin B has been elucidated by cloning and sequencing cDNA: it contains neoendorphin, dynorphin and leumorphin (containing rimorphin as its amino-terminus). These opioid peptides, each having a leucine-enkephalin structure, act on the kappa-receptor. We have now cloned a human genomic DNA segment containing the preproenkephalin B gene. The structural organization of this gene resembles those of the genes encoding the other opioid peptide precursors, that is, preproenkephalin A and the corticotropin-beta-lipotropin precursor (ACTH-beta-LPH precursor). The primary structure of human preproenkephalin B has been deduced from the gene sequence. The amino acid sequence homology observed between preproenkephalin B and preproenkephalin A, together with the similarity between their gene organizations, suggests that the two genes have been generated from a common ancestor by gene duplication.
PMID: 6316163 [PubMed - indexed for MEDLINE]
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Cited by 10 PubMed Central articles
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Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element.
Carrión AM, Mellström B, Naranjo JR.
Mol Cell Biol. 1998 Dec; 18(12):6921-9.
[Mol Cell Biol. 1998]
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A Huntington disease-like neurodegenerative disorder maps to chromosome 20p.
Xiang F, Almqvist EW, Huq M, Lundin A, Hayden MR, Edström L, Anvret M, Zhang Z.
Am J Hum Genet. 1998 Nov; 63(5):1431-8.
[Am J Hum Genet. 1998]
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Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.
Mollereau C, Simons MJ, Soularue P, Liners F, Vassart G, Meunier JC, Parmentier M.
Proc Natl Acad Sci U S A. 1996 Aug 6; 93(16):8666-70.
[Proc Natl Acad Sci U S A. 1996]
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