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Biochem Biophys Res Commun. 1983 Oct 14;116(1):86-90.

Ethylisopropyl-amiloride: a new and highly potent derivative of amiloride for the inhibition of the Na+/H+ exchange system in various cell types.


Ethylisopropyl-amiloride is 100 times more potent than amiloride for inhibiting the Na+/H+ exchanger of 3T3 fibroblasts, chick skeletal muscle cells and chick cardiac cells. Half-maximum effects, measured at 3 mM external Na+ are observed at 20-100 nM and 5 microM for ethylisopropyl-amiloride and amiloride respectively. As previously observed for amiloride, the effect of ethylisopropyl-amiloride is antagonized by external Na+ ions.

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