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The spectrum of antiviral activities of acyclovir in vitro and in vivo.
In vitro sensitivity data suggest that acyclovir should be effective against clinical manifestations of herpes simplex virus types 1 and 2, varicella-zoster virus and possibly Epstein-Barr virus. The clinical potential against herpes simplex virus types 1 and 2 is further supported by results in animal models. Human cytomegalovirus and the veterinary herpes viruses, with the possible exception of equine herpes virus type 1, may be insufficiently sensitive to be amenable to treatment.
PMID: 6313598 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Pharmacokinetics and tolerance of desciclovir, a prodrug of acyclovir, in healthy human volunteers.
Petty BG, Whitley RJ, Liao S, Krasny HC, Rocco LE, Davis LG, Lietman PS.
Antimicrob Agents Chemother. 1987 Sep; 31(9):1317-22.
[Antimicrob Agents Chemother. 1987]
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Oral acyclovir (Zovirax) in herpes simplex dendritic corneal ulceration.
Collum LM, McGettrick P, Akhtar J, Lavin J, Rees PJ.
Br J Ophthalmol. 1986 Jun; 70(6):435-8.
[Br J Ophthalmol. 1986]
Patient Drug Information
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Acyclovir (Zovirax® )
Acyclovir is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and ...