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Nature. 1983 Aug 18-24;304(5927):596-602.

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Abstract

Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.

PMID:
6308472
[PubMed - indexed for MEDLINE]
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