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Linkage of human apolipoproteins A-I and C-III genes.
It has recently been suggested that polymorphisms in the human apolipoprotein A-I (apo A-I) gene locus may be related to the development of premature atherosclerosis and hypertriglyceridaemia. To understand if and how these polymorphisms affect apo A-I gene expression, we studied the genomic sequences flanking the apo A-I gene. Here we show the presence of another apolipoprotein gene, apolipoprotein C-III (apo C-III), approximately 2.6 kilobases (kb) downstream of the 3' end of the apo A-I gene. We also show that the apo A-I and apo C-III genes are convergently transcribed and that a polymorphism previously reported to be associated with hypertriglyceridaemia may be due to a single base pair substitution in the 3'-noncoding region of apo C-III mRNA.
PMID: 6308458 [PubMed - indexed for MEDLINE]
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Cited by 22 PubMed Central articles
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Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene.
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[J Clin Invest. 1997]
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Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.
Staels B, Vu-Dac N, Kosykh VA, Saladin R, Fruchart JC, Dallongeville J, Auwerx J.
J Clin Invest. 1995 Feb; 95(2):705-12.
[J Clin Invest. 1995]
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Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino acid segment with amphipathic helical potential.
Boguski MS, Elshourbagy N, Taylor JM, Gordon JI.
Proc Natl Acad Sci U S A. 1984 Aug; 81(16):5021-5.
[Proc Natl Acad Sci U S A. 1984]
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