Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1983 Apr 14;302(5909):575-81.

Somatic generation of antibody diversity.

Abstract

In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.

PMID:
6300689
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Faculty of 1000
    Loading ...
    Write to the Help Desk