Br J Haematol. 1983 Mar;53(3):411-6.

Thalassaemia intermedia in Cyprus: the interaction of alpha and beta thalassaemia.

Wainscoat JS, Kanavakis E, Wood WG, Letsky EA, Huehns ER, Marsh GW, Higgs DR, Clegg JB, Weatherall DJ.

Abstract

Restriction endonuclease analysis has been performed on the alpha and beta globin gene clusters of 57 Cypriots homozygous for beta thalassaemia, 30 with the transfusion dependent form of the condition (thalassaemia major) and 27 who are less severely affected (thalassaemia intermedia). There was a significant difference in the incidence of alpha thalassaemia between the two groups: 14/27 of the patients with thalassaemia intermedia also had deletion forms of alpha thalassaemia, while only 4/30 of the patients with thalassaemia major were similarly affected. Thus in Cypriot patients who are homozygous for beta thalassaemia the co-inheritance of alpha thalassaemia is an important factor in determining the clinical course.

PMID:: 6297530; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Medical

Supplemental Content

Save items

Related citations in PubMed

Globin gene mapping studies in Sardinian patients homozygous for beta zero Thalassaemia. [Mol Biol Med. 1983]
Globin gene mapping studies in Sardinian patients homozygous for beta zero Thalassaemia.
Wainscoat JS, Bell JI, Old JM, Weatherall DJ, Furbetta M, Galanello R, Cao A. Mol Biol Med. 1983 Jul; 1(1):1-10.
Molecular basis for mild forms of homozygous beta-thalassaemia. [Lancet. 1981]
Molecular basis for mild forms of homozygous beta-thalassaemia.
Weatherall DJ, Pressley L, Wood WG, Higgs DR, Clegg JB. Lancet. 1981 Mar 7; 1(8219):527-9.
The molecular basis for the clinical diversity of beta thalassaemia in Cypriots. [Lancet. 1983]
The molecular basis for the clinical diversity of beta thalassaemia in Cypriots.
Wainscoat JS, Old JM, Weatherall DJ, Orkin SH. Lancet. 1983 Jun 4; 1(8336):1235-7.
Review Thalassaemia intermedia. [Blood Rev. 1987]
Review Thalassaemia intermedia.
Wainscoat JS, Thein SL, Weatherall DJ. Blood Rev. 1987 Dec; 1(4):273-9.
Review [Beta thalassemia: molecular pathogenesis and clinical variability]. [Klin Padiatr. 1991]
Review [Beta thalassemia: molecular pathogenesis and clinical variability].
Kulozik AE. Klin Padiatr. 1991 Jul-Aug; 203(4):276-83.

See reviews... See all...

Cited by 7 PubMed Central articles

Genotypic influence of α-deletions on the phenotype of Indian sickle cell anemia patients. [Korean J Hematol. 2011]
Genotypic influence of α-deletions on the phenotype of Indian sickle cell anemia patients.
Pandey S, Pandey S, Mishra RM, Sharma M, Saxena R. Korean J Hematol. 2011 Sep; 46(3):192-5. Epub 2011 Sep 30.
Beta thalassaemia trait in western Nigeria. [Afr Health Sci. 2009]
Beta thalassaemia trait in western Nigeria.
Kotila TR, Adeyemo AA, Mewoyeka OO, Shokunb WA. Afr Health Sci. 2009 Mar; 9(1):46-8.
Elastic, not plastic species: frozen plasticity theory and the origin of adaptive evolution in sexually reproducing organisms. [Biol Direct. 2010]
Elastic, not plastic species: frozen plasticity theory and the origin of adaptive evolution in sexually reproducing organisms.
Flegr J. Biol Direct. 2010 Jan 13; 5:2. Epub 2010 Jan 13.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Thalassaemia intermedia in Cyprus: the interaction of alpha and beta thalassaemi...
Thalassaemia intermedia in Cyprus: the interaction of alpha and beta thalassaemia.
Br J Haematol. 1983 Mar ;53(3):411-6.

PubMed
Mechanistic studies on the dehydrogenases of methylotrophic bacteria. 2. Kinetic...
Mechanistic studies on the dehydrogenases of methylotrophic bacteria. 2. Kinetic studies on the intramolecular electron transfer in trimethylamine and dimethylamine dehydrogenase.
Biochem J. 1982 Nov 1 ;207(2):241-52.

PubMed
Mediators of postreceptor action of insulin.
Mediators of postreceptor action of insulin.
Am J Med. 1983 Jan 17 ;74(1A):38-51.

PubMed
Retinal involvement in thoracic-pelvic-phalangeal dystrophy.
Retinal involvement in thoracic-pelvic-phalangeal dystrophy.
Arch Ophthalmol. 1978 Feb ;96(2):278-81.

PubMed
Familial nemaline myopathy.
Familial nemaline myopathy.
Neuropediatrics. 1982 Nov ;13(4):211-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: