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Mechanism of activation of a human oncogene.
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.
PMID: 6290897 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Genome wide identification of recessive cancer genes by combinatorial mutation analysis.
Volinia S, Mascellani N, Marchesini J, Veronese A, Ormondroyd E, Alder H, Palatini J, Negrini M, Croce CM.
PLoS One. 2008; 3(10):e3380. Epub 2008 Oct 10.
[PLoS One. 2008]
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ReviewThirty years into the genomics era: tumor viruses led the way.
DiMaio D, Miller G.
Yale J Biol Med. 2006 Dec; 79(3-4):179-85.
[Yale J Biol Med. 2006]
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Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones.
Behforouz M, Cai W, Mohammadi F, Stocksdale MG, Gu Z, Ahmadian M, Baty DE, Etling MR, Al-Anzi CH, Swiftney TM, et al.
Bioorg Med Chem. 2007 Jan 1; 15(1):495-510. Epub 2006 Oct 10.
[Bioorg Med Chem. 2007]
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