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Antiviral Res. 1981 Nov;1(4):203-12.

Acyclovir - a review of the preclinical and early clinical data of a new antiherpes drug.


A review of the literature on acyclovir (Zovirax), a new antiherpes drug, with particular activity against herpes simplex virus types I and II and also against varicella-zoster, Epstein-Barr, cytomegalo and herpes B viruses, is presented. The article deals with 'in vitro' and 'in vivo' efficacy in animals, animal toxicity, latency and resistance, the mechanism of action and early clinical experience.

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