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    Arch Gen Psychiatry. 1982 Jan;39(1):70-3.

    Fluphenazine vs placebo in patients with remitted, acute first-episode schizophrenia.

    Kane JM, Rifkin A, Quitkin F, Nayak D, Ramos-Lorenzi J.

    Abstract

    Twenty-eight patients who had recently recovered from an acute-onset, first-episode schizophrenic illness were randomly given fluphenazine hydrochloride or decanoate or placebo for a one-year period in a double-blind study. Seven of 17 patients(14%) receiving placebo experienced a psychotic relapse, whereas none of 11 drug-treated patients experienced a relapse. Eighteen (69%) of the 26 patients available for follow-up (mean interval, 3.5 years) experienced a second psychotic relapse either during the study or afterward, and 50% (14/28) of the original sample experienced a third episode.

    PMID:
    6275811
    [PubMed - indexed for MEDLINE]

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