Abstract
Various opiate ligands were bound to brain membranes of mice of the Recombinant Inbred System. The specific binding of low levels of [3H]naloxone, [3H]dihydromorphine and [3H]ethylketocyclazocine was disturbed in a similar fashion among the inbred strains, and in a pattern different from that observed for [3H](D-Ala2,D-Leu5)-enkephalin. The results indicate that the inbred strains differ in mu- and delta-type binding and support the concept of multiple opiate receptors in mouse brain.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / metabolism*
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Cyclazocine / analogs & derivatives
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Cyclazocine / metabolism
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Dihydromorphine / metabolism
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Enkephalin, Leucine-2-Alanine
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Enkephalins / metabolism
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Ethylketocyclazocine
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In Vitro Techniques
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Naloxone / metabolism
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Receptors, Opioid / drug effects*
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Species Specificity
Substances
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Enkephalins
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Receptors, Opioid
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Naloxone
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Ethylketocyclazocine
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Enkephalin, Leucine-2-Alanine
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Dihydromorphine
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Cyclazocine