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1: Cancer Treat Rep. 1978 Jan;62(1):1-11.Links

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

Dedrick RL, Myers CE, Bungay PM, DeVita VT Jr.

Evidence from the peritoneal dialysis literature suggests that the peritoneal permeability of a number of hydrophilic anticancer drugs may be considerably less than plasma clearance. Pharmacokinetic calculations indicate that such drugs administered ip in large volumes are expected to maintain a significantly greater concentration in the peritoneal space than in the plasma. This concentration difference offers a potentially exploitable biochemical advantage in the treatment of patients with presumed microscopic residual ovarian cancer confined to the peritoneal cavity.

PMID: 626987 [PubMed - indexed for MEDLINE]

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