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Cancer Treat Rep. 1978 Jan;62(1):1-11.

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

Abstract

Evidence from the peritoneal dialysis literature suggests that the peritoneal permeability of a number of hydrophilic anticancer drugs may be considerably less than plasma clearance. Pharmacokinetic calculations indicate that such drugs administered ip in large volumes are expected to maintain a significantly greater concentration in the peritoneal space than in the plasma. This concentration difference offers a potentially exploitable biochemical advantage in the treatment of patients with presumed microscopic residual ovarian cancer confined to the peritoneal cavity.

PMID:
626987
[PubMed - indexed for MEDLINE]
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