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    Clin Pharmacol Ther. 1981 Oct;30(4):436-8.

    Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate.

    Mackenzie TB, Popkin MK, Dziubinski J, Sheppard JR.

    Abstract

    The effect of short-term caffeine withdrawal on lymphocyte beta-adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E1 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.

    PMID:
    6269786
    [PubMed - indexed for MEDLINE]

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