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1: J Neurochem. 1981 Apr;36(4):1587-9.Links

Benzodiazepine receptors on primary cultures of mouse astrocytes.

Tardy M, Costa MF, Rolland B, Fages C, Gonnard P.

Benzodiazepines bind to glial membranes on a single type of site, with a high affinity (KD = 5 x 10(-9) M) on about 100 fmol of sites per mg protein. The number of binding sites is increased when the membranes are treated with Triton X-100. Antiepileptic drugs such as clonazepam and phenobarbital and hypnotic drugs such as Ro-11-3128 and Ro-11-6896 are able in pharmacological concentrations to displace [3H]flunitrazepam from its glial binding sites.

PMID: 6267195 [PubMed - indexed for MEDLINE]

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