Science. 1981 Jun 12;212(4500):1279-81.

Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary.

Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL.

Abstract

Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on basal or stimulated growth hormone release from primary cultures of rat adenohypophyseal cells during a 4-hour incubation, but inhibits stimulated release by more that 90 percent after 24 hours. These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.

PMID:: 6262917; [PubMed - indexed for MEDLINE]

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Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary.

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