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Science. 1980 Oct 3;210(4465):88-90.

Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.

Abstract

Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.

PMID:
6251550
[PubMed - indexed for MEDLINE]
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