Abstract
Erythrocyte metabolic abnormalities should be considered as a possible cause of hemolysis when there is no evidence of an immune-mediated hemolytic anemia, no consumptive red blood cell disorder, no morophologic or laboratory data to suggest a problem of the red cell membrane, and no evidence of a quantitative or qualitative defect in hemoglobin synthesis. Glucose-6-phosphate dehydrogenase deficiency is clearly the most common enzyme deficiency causing clinical problems.
MeSH terms
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5'-Nucleotidase
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Adenosine Deaminase / deficiency
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Adenosine Triphosphate / biosynthesis
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Anemia, Hemolytic, Congenital / enzymology
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Anemia, Hemolytic, Congenital / physiopathology
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Child
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Erythrocyte Membrane / metabolism
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Erythrocytes / metabolism
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Erythrocytes, Abnormal / enzymology*
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Glucosephosphate Dehydrogenase Deficiency / physiopathology
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Glutathione / metabolism
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Glutathione Peroxidase / deficiency
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Glutathione Reductase / deficiency
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Glutathione Synthase / deficiency
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Glycolysis
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Hemolysis
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Hexosephosphates / metabolism
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Humans
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Infant, Newborn
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Metabolism, Inborn Errors / blood*
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Nucleotidases / deficiency
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Pyrimidine Nucleotides / deficiency
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Pyruvate Kinase / deficiency
Substances
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Hexosephosphates
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Pyrimidine Nucleotides
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Adenosine Triphosphate
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Glutathione Peroxidase
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Glutathione Reductase
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Pyruvate Kinase
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Nucleotidases
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5'-Nucleotidase
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Adenosine Deaminase
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Glutathione Synthase
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Glutathione